Sarah Spiegel Selected Research

Sphingosine-1-Phosphate Receptors

11/2020	Targeting the Sphingosine-1-Phosphate Axis for Developing Non-narcotic Pain Therapeutics.
1/2020	Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents.
1/2019	Fingolimod augments Pemetrexed killing of non-small cell lung cancer and overcomes resistance to ERBB inhibition.
1/2019	Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain.
1/2015	Differential regulation of autophagy and cell viability by ceramide species.
1/2014	Sphingosine-1-phosphate in chronic intestinal inflammation and cancer.
11/2011	Targeting sphingosine-1-phosphate in hematologic malignancies.
3/2010	Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema.
9/2007	Sphingosine-1-phosphate in allergic responses, asthma and anaphylaxis.
6/2005	Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Sarah Spiegel Research Topics

Disease

54	Neoplasms (Cancer) 01/2022 - 11/2002
28	Inflammation (Inflammations) 01/2022 - 06/2003
18	Breast Neoplasms (Breast Cancer) 01/2020 - 11/2002
13	Multiple Sclerosis 10/2020 - 02/2007
10	Asthma (Bronchial Asthma) 01/2021 - 09/2002
8	Neoplasm Metastasis (Metastasis) 01/2020 - 02/2012
8	Melanoma (Melanoma, Malignant) 01/2016 - 01/2005
6	Glioma (Gliomas) 05/2015 - 04/2002
6	Leukemia 08/2008 - 04/2004
5	Non-alcoholic Fatty Liver Disease 01/2022 - 10/2017
5	Fibrosis (Cirrhosis) 01/2022 - 11/2016
5	Neuralgia (Stump Neuralgia) 11/2020 - 01/2018
5	Ovarian Neoplasms (Ovarian Cancer) 01/2019 - 10/2003
5	Hypersensitivity (Allergy) 04/2015 - 09/2002
5	Glioblastoma (Glioblastoma Multiforme) 02/2010 - 02/2008
4	Chronic Pain 11/2020 - 01/2019
4	Infections 08/2020 - 03/2010
4	Pathologic Processes 12/2016 - 01/2004
4	Carcinogenesis 01/2016 - 11/2002
4	Anaphylaxis (Anaphylactic Shock) 05/2012 - 09/2007
3	Obesity 01/2021 - 10/2017
3	Pain (Aches) 11/2020 - 09/2017
3	Triple Negative Breast Neoplasms 01/2020 - 01/2018
3	Autoimmune Diseases (Autoimmune Disease) 01/2019 - 11/2007
3	Colitis 01/2016 - 01/2014
3	Ulcerative Colitis 01/2016 - 01/2013
3	Colonic Neoplasms (Colon Cancer) 01/2014 - 08/2008
3	Carcinoma (Carcinomatosis) 08/2010 - 11/2007
3	Starvation 02/2007 - 06/2005
2	Alcoholic Fatty Liver 01/2022 - 01/2022
2	Hepatocellular Carcinoma (Hepatoma) 01/2022 - 01/2020
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2022 - 10/2017
2	Neuroinflammatory Diseases 12/2021 - 12/2015
2	Hyperalgesia 10/2020 - 01/2020
2	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 01/2020 - 12/2013
2	Lung Neoplasms (Lung Cancer) 01/2020 - 01/2019
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2017 - 04/2007
2	Pancreatic Neoplasms (Pancreatic Cancer) 10/2016 - 08/2010
2	Respiratory Hypersensitivity 10/2015 - 02/2013
2	Fistula 04/2015 - 01/2012
2	Colitis-Associated Neoplasms 01/2014 - 01/2013

Drug/Important Bio-Agent (IBA)

56	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 01/2021 - 09/2002
42	SphingolipidsIBA 12/2021 - 04/2002
35	sphingosine kinaseIBA 01/2022 - 04/2002
24	CeramidesIBA 12/2021 - 04/2002
23	LipidsIBA 01/2022 - 03/2006
23	Fingolimod Hydrochloride (FTY720)FDA Link 11/2020 - 12/2004
14	EnzymesIBA 12/2021 - 04/2002
12	Phosphotransferases (Kinase)IBA 01/2021 - 06/2008
12	CytokinesIBA 08/2020 - 02/2008
12	SphingosineIBA 01/2018 - 11/2002
11	Pharmaceutical PreparationsIBA 11/2020 - 11/2007
11	Proteins (Proteins, Gene)FDA Link 01/2019 - 02/2008
10	Sphingosine-1-Phosphate ReceptorsIBA 11/2020 - 06/2005
6	Biomarkers (Surrogate Marker)IBA 05/2021 - 08/2012
6	Epidermal Growth Factor (EGF)IBA 08/2008 - 06/2005
5	Messenger RNA (mRNA)IBA 01/2022 - 08/2008
5	ProdrugsIBA 01/2020 - 12/2004
5	LigandsIBA 12/2018 - 04/2007
5	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2016 - 04/2002
5	Interleukin-1 (Interleukin 1)IBA 01/2016 - 09/2008
5	InterleukinsIBA 03/2010 - 06/2003
4	Opioid Analgesics (Opioids)IBA 11/2020 - 01/2019
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2019 - 11/2009
4	IsoenzymesIBA 01/2018 - 09/2009
4	Interleukin-6 (Interleukin 6)IBA 01/2018 - 04/2008
4	AntigensIBA 04/2015 - 09/2002
4	Histone Deacetylase InhibitorsIBA 12/2013 - 04/2004
4	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 06/2011 - 10/2003
3	Estrogens (Estrogen)FDA Link 01/2022 - 11/2002
3	Protein Isoforms (Isoforms)IBA 01/2020 - 10/2015
3	Small Interfering RNA (siRNA)IBA 01/2019 - 10/2006
3	Pemetrexed (MTA)FDA Link 01/2019 - 07/2012
3	Estrogen ReceptorsIBA 12/2018 - 01/2016
3	Phosphates (Orthophosphate)IBA 01/2016 - 06/2005
3	ChemokinesIBA 12/2015 - 02/2013
3	Immunosuppressive Agents (Immunosuppressants)IBA 10/2015 - 12/2004
3	JTE 013IBA 04/2015 - 03/2010
3	Immunoglobulin E (IgE)IBA 02/2013 - 06/2003
3	Drug CombinationsIBA 07/2012 - 10/2008
3	Sorafenib (BAY 43-9006)FDA Link 07/2012 - 10/2008
3	lysophosphatidic acidIBA 09/2010 - 06/2005
3	Vorinostat FDA Link 08/2010 - 03/2005
3	Biological ProductsIBA 08/2008 - 10/2005
2	SugarsIBA 01/2022 - 10/2017
2	CannabinoidsIBA 12/2021 - 08/2009
2	Non-Narcotic Analgesics (Analgesics, Non Narcotic)IBA 11/2020 - 01/2019
2	Morphine (MS Contin)FDA LinkGeneric 10/2020 - 01/2020
2	Fatty Acid Synthases (Fatty Acid Synthase)IBA 02/2020 - 01/2019
2	CholesterolIBA 01/2020 - 01/2017
2	Bortezomib (Velcade)FDA Link 01/2020 - 01/2018
2	Adenosine Triphosphate (ATP)IBA 01/2018 - 01/2016
2	Histone Deacetylases (Histone Deacetylase)IBA 01/2017 - 04/2004
2	Dextrans (Dextran)FDA Link 01/2016 - 12/2015
2	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2016 - 12/2015
2	Folic Acid (Vitamin M)FDA LinkGeneric 01/2015 - 07/2012
2	Interleukin-4 (Interleukin 4)IBA 02/2013 - 05/2010

Therapy/Procedure

17	Therapeutics 11/2020 - 01/2005
5	Drug Therapy (Chemotherapy) 01/2020 - 01/2005
2	Oral Administration 01/2016 - 01/2013